Bacteroides fragilis is an opportunistic pathogen and inhabitant of the normal human colonic microbiota. B. fragilis is the major obligately anaerobic Gram negative bacterium isolated from abscesses, soft tissue infections, and bacteraemias that arise from contamination of normally uncolonized body sites by bacteria from the resident gastrointestinal (GI) microbiota. B. fragilis strain NCTC 9343 was originally isolated from an abdominal infection at St Bartholomew’s Hospital, London in 1955.
The B. fragilis strain NCTC 9343 genome is composed of a single circular chromosome of 5,205,140 bp, and was sequenced in collaboration with Dr. Sheila Patrick of the School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Dr. Garry Blakely of the Institute of Structural and Molecular Biology at the University of Edinburgh, Dr. Val Abratt of the Department of Molecular and Cell Biology at the University of Cape Town, Prof. Brian Duerden of the Department of Medical Microbiology, Cardiff University, Prof. Ian Poxton of the Department of Medical Microbiology, University of Edinburgh.
A manuscript describing the NCTC 9343 genome has been published: Cerdeño-Tárraga et al. (2005) Extensive DNA Inversions in the B. fragilis Genome Control Variable Gene Expression. Science 307:1463-1465.
Please address all sequencing and annotation enquiries to Dr. Julian Parkhill.