Bordetella parapertussis is a Gram-negative beta-proteobacteria that colonize the respiratory tracts of mammals. B. parapertussis infects both humans and sheep; in human infants it causes whooping cough. Phylogenetic analyses have shown that B. parapertussis strains isolated from humans are distinct from those isolated from sheep, and there is little or no transmission between the two reservoirs (sheep and human). B. parapertussis strain 12822 is a recent human clinical isolate, and was isolated in Erlangen, Germany, during a prospective surveillance program.
The B. parapertussis strain 12822 genome is composed of a single circular chromosome of 4,773,551 bp, and was sequenced in collaboration with Prof. Duncan Maskell and Dr. Andrew Preston of the Centre for Veterinary Science, Dept. of Clinical Veterinary medicine, University of Cambridge.
A manuscript describing the 12822 genome has been published: Parkhill et al. (2003) Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nature Genet. 35:32-40.
Please address all sequencing and annotation enquiries to Dr. Julian Parkhill.