Echinococcus multilocularis is a member of the Cyclophyllidea, which comprise the majority of tapeworms that are of medical importance. The disease alveolar echinococcosis, which is caused by the larval stage of E. multilocularis , is considered to be one of the most dangerous worm infections in the world. Larval stages of the related tapeworms E. granulosus and Taenia solium cause the serious and life-threatening diseases cystic echinococcosis and neurocysticercosis, respectively. While E. granulosus , T. solium and T. saginata have a worldwide distribution E. mulitlocularis has a limited distribution within the Northern Hemisphere. However, recent data indicate a spread of E. multilocularis in Europe, Japan, and North America to areas that were previously free of the parasite leading to the classification of alveolar echinococcosis as an emerging zoonosis.
This is a Wellcome Trust funded project to sequence the nuclear genome of E. multilocularis, in collaboration with Prof. Klaus Brehm of Institute for Hygiene and Microbiology, University of Wurzburg. The assembled sequence data suggests the genome of E. multilocularis is approximately 110 MB and is being produced by whole genome shotgun sequencing using a mixture of capillary sequencing, illumina sequencing and 454 pyrosequencing. We are also profiling the transcriptome of different life cycle stages of this organism using RNA-seq.
This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. For further information see our data release policy.
Please address all sequencing and annotation enquiries to Nancy Holroyd.