P. yoelii yoelii is one of the four malaria species that infect murine rodents from Central Africa that are infectious to laboratory rodents and easily maintained and transmitted by "Anopheles stephensi" in the laboratory. It serves as a good model for the human parasites with which it shares high homology in most essential aspects of structure, biochemistry and life cycle. Genome organisation is conserved between rodent and human parasites and the two share detailed synteny.
P. yoelii yoelii has an estimated genome size of 21 Mb, with 14 chromosomes in the size range of 0.6 Mb to 3.8 Mb.
The genome of P. yoelii yoelii YM has been published A comprehensive evaluation of rodent malaria parasite genomes and gene expression.
» Plasmodium yoelii YM on GeneDB
Version 1 of P. yoelii yoelii YM is now available
A first-pass assembly and annotation of P. yoelii yoelii YM is now publicly available on GeneDB (January 2012). The assembly was made using short-fragment Illumina reads and scaffolded with 454 paired-reads from a 3kb library. The assembly was computationally improved using PAGIT (http://www.sanger.ac.uk/resources/software/pagit/) and annotated by transfer from the P. berghei ANKA reference. Genes in subtelomeric regions were predicted ab initio. The annotation has been manually re-inspected genome-wide. EMBL and GFF format files can be downloaded from the FTP site.
A publication describing the new sequence is in preparation and permission should therefore be obtained before undertaking genome-scale or whole chromosome wide analyses.
This work was funded by the Wellcome Trust Sanger Institute and the European Union's 7th Framework Programme (FP7/2007-2013) under grant agreement n°242095. The DNA was provided by Tony Holder and Solabomi Ogun (Division of Parasitology, MRC National Institute for Medical Research, Mill Hill, London).