Burkholderia pseudomallei GeneDB

The Sanger Institute has been funded to sequence the genome of Burkholderia pseudomallei in collaboration with Dr. Rick Titball of the Defence Evaluation Research Agency, Porton Down, and Dr. Ty Pitt of the Central Public Health Laboratory. We will sequence strain K96243, a clinical isolate from Thailand, supplied by Dr. S. Songsivilai of Mahidol University.

Burkholderia pseudomallei (previously called Pseudomonas pseudomallei) is the causative agent of melioidosis, a serious disease of man and animals that occurs primarily in S.E. Asia, N. Australia and other tropical areas. There is no licensed vaccine against meliodosis, and the bacterium is resistant to many antibiotics.

The sequence is now finished, and is available for download from our FTP site.

The genome is 7,247,547 bp in size with a G+C content of 68.06% consisting of two chromosomes of 4,074,542 bp and 3,173,005 bp.

"Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei" Proc. Natl. Acad. Sci. USA 101 14240-14245 (doi/10.1073/pnas.0403302101).

M.T.G. Holden, R.W. Titball, S.J. Peacock, A.M. Cerde??o-T??rraga, T. Atkins, L.C. Crossman, T. Pitt, C. Churcher, K. Mungall, S.D. Bentley, M. Sebaihia, N.R. Thomson, N. Bason, I.R. Beacham, K. Brooks, K.A. Brown, N.F. Brown, G.L. Challis, I. Cherevach, T. Chillingworth, A. Cronin, B. Crossett, P. Davis, D. DeShazer, T. Feltwell, A. Fraser, Z. Hance, H. Hauser, S. Holroyd, K. Jagels, K. E. Keith, M. Maddison, S. Moule, C. Price, M.A. Quail, E. Rabbinowitsch, K. Rutherford, M. Sanders, M. Simmonds, S. Songsivilai, K. Stevens, S. Tumapa, M. Vesaratchavest, S. Whitehead, C. Yeats, B. G. Barrell, P.C.F. Oyston and J. Parkhill

See the B. pseudomallei project pages for more information.