• search for a gene by name or synonym
• browse by product and SWISS-PROT keyword listing
• search the whole site, similar to Google (TM)
• access gene pages displaying information about a particular gene and its product
• access up to date links to external databases (EMBL, PubMed, SWISS-PROT, InterPro, Pfam, Prints, Prosite, SMART)
• search for homologies to sequences in GeneDB

All the genes are categorized according to the current knowledge associated with that particular gene and its predicted protein product. The links listed below show examples of what an entry in GeneDB looks like and to what level different genes and corresponding products are annotated to.

Example gene page	This example page is a copy of a gene page, providing a summary and additional notes (in red) describing the data sources and content.
Characterised genes	actin a   cysteine protease A
Inferred function	acyltransferase, putative succinate dehydrogenase, putative
Conserved hypothetical	LmjF31.0640 LmjF.0700
Sequence orphan	LmjF31.0530 LmjF04.0510

• publish a regular bulletin to keep the community informed, published biannually from early 2002
• develop a relational database, allowing more complicated queries and more sophisticated data management
• develop the functional specifications further
• include the sequence and annotation of chromosomes and genes from other sequencing centres
• add help pages and a tutorial to enable users at all levels access to the data

The sequencing and annotation of the L. major Friedlin genome is well advanced. Chromosomes 1,3,4 and 5 are complete, ALL other chromosomes are in sequencing.

As sequencing and annotation are "in progress" the information is continuously updated within GeneDB.

Guidelines for a unified genetic nomenclature for Leishmania and Trypanosoma were published by Clayton et al. in 1998 (Molecular and Biochemical Parasitology 97: 221-224) (paper in PDF format, reproduced with permission). This proposed nomenclature is adapted from the accepted Saccharomyces cerevisiae nomenclature and the wild-type naming is briefly summarized below:

1. Wild-type genes are in italicised upper case
2. Several functional alleles are distinguished by addition of hyphenated numbers
3. Related but non-identical genes are distinguished by adding letters or numbers without hyphenation
4. The source organism can be indicated by addition of italicised prefix
5. RNA products have the same upper case, italicised designation as the corresponding gene
6. Protein products have the same upper case (non-italicised) designation as the corresponding gene
7. Promoters are denoted by subscripts

In addition, the paper also describes the designation of mutations, genetic manipulation and gene naming. Over time, this nomenclature, after consultation with the relevant communities, will also be adopted for the genes and their products displayed in GeneDB.

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