Leishmania infantum GeneDB

The genome of L. infantum is the second Leishmania spp to be sequenced at the Sanger Institute. The clone used was generated a whole genome shotgun sequence to ~5x coverage of L. infantum clone JPCM5 (MCAN/ES/98/LLM-877). This pathogen is the causitive agent of visceral leishmaniasis in the Mediterranean basin. This project is a collaboration with Professor Debbie Smith (Imperial College) and Professor Jeremy Mottram (University of Glasgow). Gene prediction and annotation has been partly generated and analysed by comparison to the L. major genome. As sequencing and annotation are in progress, the data is continually updated.

Version 3 of the Leishmania infantum is now available. The dataset is a preliminary attempt at ordering and annotating the shotgun data. Assembled contigs have been artificially ordered into pseudomolecules representing the 36 chromosomes based on conservation with Leishmania major. Sequence gaps exist within these assembled contigs. Users should be aware of the preliminary nature of the assembly which will improve as finishing continues. Annotation has been transfered to the predicted genes from the orthologs in Leishmania major. Old systematic identifyers from version 1 can be found by typing the old identifyer into the the full content search box on this page

8184 genes in GeneDB
20 April 2007
28 March 2008
Orthologue links between the Leishmania species updated
15 February 2008
Leishmania mexicana shotgun reads are now available to download from our ftp site and for searching from the L. major blast server..
February 2008
Revisions of Leishmania infantum chromosomes 12 and 22 now available in GeneDB.
October 2007
Stage specific expression data included (PMID:17884972)