Streptomyces coelicolor GeneDB

The Sanger Institute has completed the sequencing of the Streptomyces coelicolor A3(2) genome in collaboration with Prof. David Hopwood of the John Innes Centre.

The chromosome is 8,667,507bp long with a G+C content of 72.1% and is predicted to contain 7825 protein encoding genes.

Streptomyces coelicolor A3(2) is the model representative of a group of soil-dwelling organism with a complex lifecycle involving mycelial growth and spore formation. These microbes are notable for their production of pharmaceutically useful compound including anti-tumour agents, immunosupressants and over two-thirds of all natural antibiotics currently available. The sequence was generated using a clone-by-clone approach, initially using cosmids generated and mapped by David Hopwood's group at the John Innes Centre, and latterly using a BAC library to fill gaps and confirm the map.

This data described in: S. D. Bentley et al    Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) ,Nature 417, 141 - 147 (09 May 2002) (Online version of this article at Nature)