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Trypanosoma brucei

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Example Genes

All the genes are categorized according to the current knowledge associated with that particular gene and its predicted protein product. Please note that the sequencing strain is TREU927/4 GUTat10.1 and that the majority of known/characterised genes displayed through GeneDB were identified through homology with genes identified in strain 427.

Each page represents a gene or a gene prediction, providing (where available):
  • DNA and protein sequences
  • predicted physical properties
  • domain information
  • literature links
  • similarity information
  • additional curated data
  • GO annotation
  • curated orthologues
  • protein family cluster information

The links listed below show examples of what an entry in GeneDB looks like and to what level different genes and corresponding products are annotated to.
Example gene page This example page is a copy of a gene page, providing a summary and additional notes (in red) describing the data sources and content.
Characterised genes on chromosome I cPGK-8   G6PI
Inferred function Tb927.1.2450
Conserved hypothetical Tb927.1.4250

Types of gene names
Tb927. systematic identifiers assigned to genes on finished chromosomes
(e.g. Tb927.1. identifies a gene on chromosome I)
Tb09.160.2970temporary systematic identifier assigned to coding sequences on chromosomes IX - XI. Please note that these don't constitute the final gene names.

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Up to date statistics
Below are the statistics for the current release (version 4) of the T. brucei genome. Please note that these figures include gene models on the additional, unordered contigs from chrIX-XI as well as from the additional BACs sequenced by both TIGR and Sanger.
  
total number of coding sequences (inc. pseudogene): 10490
number of manually predicted CDSs: 10490: 476 (experimentally characterised)
    2819 (role inferred from sequence similarity)
    4750 (conserved hypothetical)
    1166 (hypothetical proteins inc. 612 hypothetical protein, unlikely)
    1279 (pseudogenes)
total number of rRNAs 106
total number of tRNAs 65
number of SLRNAs (assembly could not be fully resolved) >28
total number of snRNA 6
total number of snoRNA 353
number of SRP RNA 1
Number of database cross-references BRENDA 653
  EMBL 63
  UniProt (Swiss-Prot/SPTrEMBL) 26355
  InterPro 5922
  Pfam 8670
  PRINTS 294
  ProDom 229
  PROSITE 3040
  SMART 636
  PDB 7
  PubMed 1182
  cross-links to L. major 7055
  cross-links to T. cruzi 15054
Genes annotated to GO Process nodes 3287
Genes annotated to GO Function nodes 3435
Genes annotated to GO Component nodes 2895
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Miscellaneous
Trypanosomatids: genomes and biology, a special two disc set of CD-ROMs has been produced to mark the publication of the genome sequences of the three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi.
Content
The CDs are targeted at researchers in trypanosomiasis and leishmaniasis, other parasitologists and molecular biologists. The two CDs contain:
  • the genome sequences of the three parasites
  • a slimmed down version of GeneDB for navigation of the genome sequence and annotation
  • the genome papers
  • introductory interactive tutorials on disease biology
  • a collection of over 100 annotated images
  • additional resources Development of these CDs has been co-funded by WHO/TDR, the Wellcome Trust and GeneDB on behalf of the Tritryp sequencing consortium.
    To obtain a free copy of the CD set, please contact:
    WHO/TDR
    20 Avenue Appia
    1211 Geneva 27
    Switzerland
    Tel.: + 41 22 7913725
    Fax: + 41 22 7914854
    E-mail: tdr@who.int
    http://www.who.int/tdr/media/multimedia.htm
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